Plenary Session Recordings

The PAME meeting recordings and speaker slides are available below. We also encourage you to visit the virtual PAME Memory Wall that honors loved ones lost to an epilepsy-related cause. The smiling faces and sweet memories remind us of our work’s urgency to understand and prevent epilepsy-related mortality. View the PAME Memory Wall.

Opening Sessions

  • Gardiner Lapham, RN, MPH
  • Jeffrey Buchhalter, MD
  • Tom Stanton

Meeting in the middle? Bidirectional lessons for SUDEP from basic and clinical research today

The basic science plenary session will cover lessons from either the basic science side or clinical side and evaluate how well they translate from bench to bedside and back. We will consider what else needs to be known to make smooth translation, focusing on spreading depolarization/circuit mechanisms, biomarkers (including postictal generalized EEG suppression and heart rate variability), and neurotransmitters. A panel discussion and questions from the audience will close the session.

Moderators:

  • Gordon Buchanan, MD, Ph.D., University of Iowa
  • Franck Kalume, Ph.D., Seattle Children’s Research Institute

Faculty:

  • Detlev Boison, Ph.D., Rutgers University
  • Isamu Aiba, Ph.D., Baylor College of Medicine
  • Mark Stewart, MD, Ph.D., SUNY Downstate Health Sciences University

Studying SUDEP – best practices for epidemiologic and intervention studies

This plenary session will explore important methodological considerations for studying SUDEP, including intervention trial design, selecting a study population, and appropriate outcomes and biomarkers. Speakers will also explore efforts to use data from electronic medical records to study SUDEP, as well as the latest in SUDEP surveillance. A panel discussion and questions from the audience will close the session.

Moderator:

  • Elizabeth J. Donner, MD, MSc, FRCPC, University of Toronto

Faculty:

  • Sharyn Parks-Browne, Ph.D., MPH, Centers for Disease Control and Prevention
  • Zach Grinspan, MD, MS, Weill Cornell Medicine
  • Professor Philippe Ryvlin, University Hospital of Lausanne (CHUV), Switzerland

Navigating the psychological impacts of epilepsy on the individual & family – Living with uncertainty and surviving loss

This session will discuss the mental health challenges of living with epilepsy, as well as the challenges associated with the complicated grief of losing a loved one. New research will be presented that sheds light on understanding grief, along with improved tools to better diagnose and manage anxiety and depression and reduce the risk of suicide. A panel discussion will close the session with diverse perspectives on the need for increased focus on mental health within the epilepsy community.

Moderators:

  • Gardiner Lapham, RN, MPH, BAND Foundation
  • Tom Stanton, Danny Did Foundation

Faculty:

  • Heidi M. Munger Clary, MD, MPH, FACNS, Wake Forest School of Medicine
  • Madison Berl, Ph.D., ABPP-CN, Children’s National
  • Refugio Sepulveda. Ph.D., MPH, MPA, University of Arizona
  • Hannah Whitten, Whitten-Newman Foundation
  • Jeffrey Buchhalter, MD, Epilepsy Learning Healthcare System, Pediatric Epilepsy Learning Healthcare System
  • Alison Kukla, MPH, Epilepsy Foundation

Hot Topics in Mortality in Epilepsy Research

This plenary session featured short oral presentations of mortality-related abstracts submitted for the PAME Meeting or AES Annual Meeting, focusing on research conducted by early career scientists. Basic science and clinical researchers selected to present the latest on mortality in epilepsy for this session received special recognition from PAME.

Moderator:

  • George Richerson, MD, Ph.D., University of Iowa

Family speaker:

  • Lisa Cotton, CURE Epilepsy

Hot Topics Presentations:

  • Amir Aschner, Ph.D.: Investigating Risk Factors for SUDEP in Dravet Syndrome
  • Mojtaba Dayyani, MD: Periictal cardiovascular changes in partial and generalized convulsive seizures
  • Jiayang Liu, Ph.D.: Tissue oxygenation dynamics in spontaneous seizure and seizure/spreading depolarization (SD) events in a rodent model of temporal lobe epilepsy
  • Benjamin Owen, Ph.D.: Targeted interruption of synaptic outflow of an extended amygdala nucleus reduces seizure-related death in the DBA/1 audiogenic mouse model of SUDEP
  • Maryam J. Syed, MBBS: Understanding the Effect of Hospital Safety-Net Burden on Inpatient Outcomes Following Status Epilepticus
  • Frida A. Teran, Ph.D.: Seizures cause prolonged impairment of ventilation, CO2 chemoreception, and thermoregulation via a serotonergic mechanism