The PAME Conference invites abstract submissions that further understanding of important and emerging topics related to all epilepsy-related mortality.  Below is a recent collection of abstracts:



Basic Research

Neocortical parvalbumin-positive fast-spiking GABAergic interneurons exhibit persistent deficits in axonal function in an experimental mouse model of Dravet syndrome (Scn1a+/- mice)

Authors: Keisuke Kaneko, Children’s Hospital of Philadelphia; Ethan Goldberg – Children’s Hospital of Philadelphia

 

5HT2A receptor antagonist ketanserin reversed the suppressant effects of 5-HTP on seizure-induced respiratory arrest in the DBA/1 mouse SUDEP model

Authors: Yue Shen, Zhejiang University School of Medicine; HaiXiang Ma – Zhejiang Chinese Medical University; XiTing Lian – Zhejiang University School of Medicine; LeYuan Gu – Zhejiang Chinese Medical University; Qian yu – Zhejiang Chinese Medical University; Jianliang Sun – Zhejiang University School of Medicine; Yi Shen – Zhejiang University School of Medicine; Yu Dong Zhou – Zhejiang University School of Medicine; HongHai Zhang – Zhejiang University School of Medicine

 

The Effect of Serotonergic Neurotransmission and Sleep State on Breathing During and After Kindled Seizures

Authors: Katelyn Joyal, University of Iowa; Alexandra Petrucci – University of Iowa; Mydirah Littlepage-Saunders – University of Iowa; Gordon Buchanan – University of Iowa

 

A ketogenic diet increases latency to seizure-induced respiratory arrest in DBA/1 mice

Authors: Megan Crotts, University of Iowa, The National Institite of Neurologic Diesease and Stroke Center for SUDEP Research; Frida Teran – University of Iowa, The NINDS Center for SUDEP Research; Eduardo Bravo – University of Iowa; George Richerson – University of Iowa

 

5-HT2A Receptors Are Implicated in Seizure-Induced Respiratory Arrest in DBA/1 Mice

Authors: Yundan Pan, Massachusetts General Hospital and Harvard Medical School; Zheren Tan – Massachusetts General Hospital and Harvard Medical School; Hua-Jun Feng – Massachusetts General Hospital and Harvard Medical School

 

Evaluation of Potential Mechanisms of SUDEP in a Mouse Model of Dravet Syndrome

Authors: Min-Jee Goh, University of Utah; Ana Beatriz DePaula-Silva – University of Utah; E. Jill Dahle – University of Utah; Glenna Wallis – University of Utah; Laura Bell – University of Utah; Cameron S. Metcalf – University of Utah

 

Galanin Agonists as a Novel Neurotherapeutic Strategy for SUDEP

Author: Cameron Metcalf, University of Utah

 

Altered excitability of the brainstem vagus nerve dorsal motor nucleus in the Scn1b null mouse model of Dravet Syndrome

Authors: Yukun Yuan, University of Michigan Medical School; Heather O’Malley – University of Michigan Medical School; Yan Chen – University of Michigan Medical School; Chunling Chen – University of Michigan Medical School; Larassa Robinson-Cooper – University of Michigan Medical School; Lori Isom – University of Michigan Medical School

 

Heart-specific Kv1.1 deficiency impairs cardiac repolarization without altering lifespan, cardiac contractility, or arrythmia susceptibility

Authors: Kelsey Paulhus, Southern Methodist University; Krystle Trosclair – Louisiana State University Health Sciences Center; Man Si – Southern Methodist University; Megan Watts – Louisiana State University Health Sciences Center; Kathryn Hamilton – Louisiana State University Health Sciences Center; Shenuarin Bhuiyan – Louisiana State University Health Sciences Center; Paari Dominic – Louisiana State University Health Sciences Center; Edward Glasscock – Southern Methodist University

 

Activation of Oxygen-Conserving Reflexes during Seizures as a Mechanism for Sudden Death

Authors: Ryan Budde, Purdue University; Ethan Biggs – Purdue University; John Jefferys – Oxford University; Pedro Irazoqui – Purdue University

 

Early postnatal mTOR inhibitor treatment in a mouse model of TSC with epilepsy delays onset of hyperexcitability, epilepsy, and mortality

Authors: Luis Martinez, Texas Children’s Hospital and Baylor College of Medicine; Wai Ling Lee – Baylor College of Medicine; Gabriella D’Arcangelo – Department of Cell Biology and Neuroscience, Rutgers State University of New Jersey; Xiaolong Jiang – Texas Children’s Hospital and Baylor College of Medicine; Anne Anderson – Baylor College of Medicine

 

Gas challenge tests unmask risks for sudden unexpected death in epilepsy (SUDEP) and non-SUDEP fatalities in Leigh syndrome

Authors: Angela Bard, Seattle Children’s Research Institute; Jiyun Ryu – Seattle Children’s Research Institute; Franck Kalume – Seattle Children’s Research Institute, University of Washington

 

Persistent cardiac arrhythmias in long-term recordings following intrahippocampal kainate induction of status epilepticus in mice

Authors: Amber Levine, Baylor College of Medicine; Heather Born – Baylor College of Medicine; Yi-Chen Lai – Baylor College of Medicine; Anne Anderson – Baylor College of Medicine

 

Central Apnea and Seizures in a COVID-19 Pediatric Patient

Authors: Stephanie Enner, Cohen Children’s Medical Center; Sanaya Hormozdyaran – Cohen Children’s Medical Center; Robin Varughese – Cohen Children’s Medical Center; Jennifer Milillo – Cohen Children’s Medical Center; Ivan Pavkovic – Cohen Children’s Medical Center; Emma Laureta – Cohen Children’s Medical Center; James Schneider – Cohen Children’s Medical Center; Sanjeev Kothare – Cohen Children’s Medical Center

 

Seizure-induced activation of the HPA axis worsens epilepsy outcomes and comorbidities

Authors: Trina Basu, Tufts University; Pantelis Antonodiou – Tufts University; Jamie Maguire – Tufts University

 

Scn1b deletion results in sinoatrial node dysfunction, atrial remodeling, and increased susceptibility to atrial fibrillation in addition to developmental and epileptic encephalopathy

Authors: Nnamdi Edokobi, University of Michigan; Roberto Ramos-Mondragon – University of Michigan; Alexandra Bouza – University of Michigan; Chandrika Canugovi – University of Michigan; Lena Juratli – University of Michigan-Dearborn; Sami Noujaim – University of South Florida; Nageswara Madamanchi – University of Michigan; Marschall Runge – University of Michigan; Luis Lopez-Santiago – University of Michigan; Lori Isom – University of Michigan Medical School

 

Heterogeneous Roles of the Central Amygdala (CeA) in postictal modulation of breathing and Induce Sudden Unexpected Death in Epilepsy (SUDEP).

Authors: Eduardo Bravo, University of Iowa; Anthony Marincovich – University of iowa; Frida Teran – University of Iowa, The NINDS Center for SUDEP Research; Megan Crotts – University of Iowa, The NINDS Center for SUDEP Research; George Richerson – University of Iowa

 

Increased Propensity for Pharmacologically Induced Seizures and Sudden Death in Long QT Syndrome Rabbits

Authors: Cameron Bosinski, State University of New York Upstate Medical University; Kyle Wagner – State University of New York Upstate Medical University; David Auerbach – State University of New York Upstate Medical University

 

GTCS Semiology of Epileptic Baboons: Does Postictal Myoclonus Protect Baboons from SUDEP?

Authors: Charles Szabo, University of Texas Health San Antonio; David Gonzalez – UT Health San Antonio; Sreekanth Koneru – UT Health San Antonio

 

Scn8a N1768D/+ mice show impaired inter-ictal CO2 chemoreception and seizure-induced death due to central apnea

Authors: Frida Teran, University of Iowa, The National Institute of Neurologic Disorders and Stroke Center for SUDEP Research; Eduardo Bravo – University of Iowa; George Richerson – University of Iowa

 

Kv1.1 Potassium Channel Subunit Deficiency Alters Ventricular Repolarization, Arrhythmia Susceptibility, and Contractility

Authors: Krystle Trosclair, Louisiana State University Health Sciences Center; Man Si – Southern Methodist University; Megan Watts – Louisiana State University Health Sciences Center; Paari Dominic – Louisiana State University Health Sciences Center; Shenuarin Bhuiyan – Louisiana State University Health Sciences Center; Kathryn Hamilton – Louisiana State University Health Sciences Center; Edward Glasscock – Southern Methodist University

 

Clinical Research

Derivation of Prediction Models for Early and Late Mortality in Epilepsy that Include Modifiable Risk Factors Using Electronic Health Records

Authors: Marianne Hrabok, Cumming School of Medicine, University of Calgary; Jordan Engbers – Desid Labs Inc; Samuel Wiebe – Cumming School of Medicine, University of Calgary; Tolulope Sajobi – Cumming School of Medicine, University of Calgary; Ann Subota – Cumming School of Medicine, University of Calgary; Amal Almohawes – Cumming School of Medicine, University of Calgary; Paolo Federico – Cumming School of Medicine, University of Calgary; Alexandra Hanson – Cumming School of Medicine, University of Calgary; Karl Martin Klein – Cumming School of Medicine, University of Calgary; Joseph Peedicail – Cumming School of Medicine, University of Calgary; Neelan Pillay – Cumming School of Medicine, University of Calgary; Shaily Singh – Cumming School of Medicine, University of Calgary; Colin Josephson – Cumming School of Medicine, University of Calgary

 

Identifying cardiac genetic biomarkers to predict the risk of sudden unexplained death in epilepsy

Authors: Ming Soh, The Florey Institute of Neuroscience and Mental Health, University of Melbourne; Richard Bagnall – Molecular Cardiology Program, Centenary Institute; Lauren Bleakley – The Florey Institute of Neuroscience and Mental Health, University of Melbourne; A. Marie Phillips – The Florey Institute of Neuroscience and Mental Health, University of Melbourne; Chaseley Mckenzie – The Florey Institute of Neuroscience and Mental Health, University of Melbourne; Erlina Mohamed Syazwan – The Florey Institute of Neuroscience and Mental Health, University of Melbourne; Christopher Semsarian – Molecular Cardiology Program, Centenary Institute; Ingrid Scheffer – Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC, Australia; Samuel Berkovic – Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC, Australia; Christopher Reid – The Florey Institute of Neuroscience and Mental Health, University of Melbourne

 

Seizure Detection using Wearable Sensors and Machine Learning: Setting a Benchmark

Authors: Jianbin Tang, IBM Research Australia; Rima El Atrache – Boston Children’s Hospital, Harvard Medical School; Umar Asif – IBM Research Australia; Michele Jackson – Boston Children’s Hospital, Harvard Medical School; Subhrajit Roy – IBM Research Australia; Theodore Sheehan – Boston Children’s Hospital, Harvard Medical School; Mahtab Mirmomeni – IBM Research Australia; Claire Ufongene – Boston Children’s Hospital, Harvard Medical School; Sarah Schubach – Boston Children’s Hospital, Harvard Medical School; Solveig Vieluf – Boston Children’s Hospital, Harvard Medical School; Christian Meisel – Boston Children’s Hospital, Harvard Medical School; Stefan Harrer – IBM Research Australia; Tobias Loddenkemper – Boston Children’s Hospital, Harvard Medical School

 

Population-Based Surveillance of Sudden Unexpected Death in Epilepsy using the Sudden Death in the Young Case Registry

Authors: Vicky Whittemore, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Kristin M Burns – NIH; Michelle Udine – Children’s National Hospital; Esther Shaw – MPHI; Meghan Faulkner – MPHI; Niu Tian – Centers for Disease Control and Prevention

 

Predictor Risk Factors of In-patient Mortality in Status Epilepticus

Authors: Nassim Naderi, University of Texas, Health Science Center at Houston; Aditya Kumar – University of Texas, Health Science Center at Houston; Louise McCullough – University of Texas, Health Science Center at Houston

 

Predictor Risk Factors of Acute Respiratory Failure in Status Epilepticus: Data from the Nationwide Inpatient Sample (NIS)

Authors: Yvo Rodriguez, University of Texas, Health Science Center at Houston; Niyousha Naderi – University of Texas, Health Science Center at Houston; Shivika Chandra – University of Texas, Health Science Center at Houston; Nassim Naderi – University of Texas, Health Science Center at Houston

 

Cardiac Mechanisms in Sudden Unexpected Death in Epilepsy (SUDEP) with DEPDC5 Loss-of-Function

 

Association Between Generalized Tonic-Clonic Seizure and Cardiopulmonary Risk

Authors: Yanting Zhao, University of Michigan; Helen Zhang – University of Michigan; Jack Parent – Michigan Medicine; Lori Isom – University of Michigan Medical School

 

Apneas Persisting Beyond Amygdala Stimulation or Seizure Activity

Authors: Gail Harmata, University of Iowa; Ariane Rhone – University of Iowa Hospitals & Clinics; Christopher Kovach – University of Iowa Hospitals & Clinics; Matthew Howard – University of Iowa Hospitals & Clinics; George Richerson – University of Iowa; John Wemmie – University of Iowa Hospitals & Clinics; Brian Dlouhy – University of Iowa Hospitals & Clinics

 

Ictal central apnea in patient with medically intractable epilepsy

Authors: Katherine Schwartz, Rush University Medical Center; Antoaneta Balabanov – Rush University Medical Center; Alejandra Lastra – Rush University Medical Center

 

Natural History of Mortality in Individuals with Tuberous Sclerosis Complex

Authors: Shridhar Parthasarathy, The College of New Jersey; Rajeshwari Mahalingam – Institute of Neurology and Neurosurgery; Orrin Devinsky – New York University Langone Medical Center

 

The prevalence of REM sleep onset seizures in a cohort of patients who died of SUDEP

Authors: Lilach Goldstein, Thomas Jefferson University Hospital; Roozbeh Tarighati Rasekhi – Thomas Jefferson University Hospital; Michael Sperling – Thomas Jefferson University Hospital; Maromi Nei – Thomas Jefferson University Hospital

 

Time of day is an inaccurate surrogate for sleep-wake state in the epilepsy monitoring unit

Authors: Kevin Ha, University of Virginia; Andrew Schomer – University of Virginia; Juliana Leonardo – University of Virginia; Mark Quigg – University of Virginia

 

Status Epilepticus: Inpatient Burden of Illness and Association with Disease Severity

Authors: Elan Guterman, University of California, San Francisco; John Betjemann – University of California, San Francisco; Alex Aimetti – Marinus Pharmaceuticals, Inc.; Justin Li – Trinity Life Sciences; Zheng Wang – Trinity Life Sciences,; David Yin – Trinity Life Sciences; Joseph Hulihan – Marinus Pharmaceuticals, Inc.; Thomas Lyons – Marinus Pharmaceuticals, Inc., Radnor, PA; Gavin Miyasato – Trinity Life Sciences, Waltham, MA; Adam Strzelczyk -Goethe University

 

Evaluating the risks for SUDEP at night: depth of sleep predicts postictal heart rate

Authors: Andrew Schomer, University of Virginia; Morgan Lynch – University of Virginia; Juliana Leonardo – University of Virginia; Valentina Baljak – University of Virginia; Matthew Clark – Advanced Medical Predictive Devices; J Randall Moorman – University of Virginia; Jaideep Kapur – University of Virginia; Mark Quigg – University of Virginia

 

Central Apnea and Seizures in a COVID-19 Pediatric Patient

Authors: Stephanie Enner, Cohen Children’s Medical Center; Sanaya Hormozdyaran – Cohen Children’s Medical Center; Robin Varughese – Cohen Children’s Medical Center; Jennifer Milillo – Cohen Children’s Medical Center; Ivan Pavkovic – Cohen Children’s Medical Center; Emma Laureta – Cohen Children’s Medical Center; James Schneider – Cohen Children’s Medical Center; Sanjeev Kothare – Cohen Children’s Medical Center

 

Machine learning from wristband sensor data for wearable, non-invasive seizure forecasting

Authors: Christian Meisel, Boston Children’s Hospital; Rima El Atrache – Boston Children’s Hospital, Harvard Medical School; Michele Jackson – Boston Children’s Hospital, Harvard Medical School; Sarah Schubach – Boston Children’s Hospital, Harvard Medical School; Claire Ufongene – Boston Children’s Hospital, Harvard Medical School; Tobias Loddenkemper – Boston Children’s Hospital, Harvard Medical School

 

Network localisation of cardiorespiratory dysfunction in focal epilepsy

Authors: Eugenio Abela, King’s College London; Nira Futter – King’s College London; Andrea Biondi – King’s College London; Pedro Viana – King’s College London; Mark Richardson – King’s College London

 

A Novel and Unexpected Marker of Risk for Seizures on EMU admission: Elevated EKG Heterogeneity

Authors: Trudy Pang, Beth Israel Deaconess Medical Center; Bruce Nearing – Beth Israel Deaconess Medical Center; Steven Schachter – Beth Israel Deaconess Medical Center; Richard Verrier – Beth Israel Deaconess Medical Center

 

Autonomic Dysfunction Is More Prominent in Patients with Focal Rather Than with Generalized Epilepsy

Authors: Alla Guekht, Moscow Research and Clinical Center for Neuropsychiatry; Anna Lebedeva – Pirogov Russian National Research Medical University; Marina Lebedeva – Institute of General Pathology and Pathophysiology; Flora Rider – Moscow Research and Clinical Center for Neuropsychiatry; Yury Solomatin – Moscow Research and Clinical Center for Neuropsychiatry; Anna Teplyshova – Moscow Research and Clinical Center for Neuropsychiatry; Alexander Yakovlev – Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences; Dmitry Zhuravlev – Moscow Research and Clinical Center for Neuropsychiatry; Max Hilz – Icahn School of Medicine at Mount Sinai

 

Other Research

Screening for suicidality and its relation to undiagnosed psychiatric co-morbidities in children and youth with epilepsy

Authors: Anjali Dagar, Cleveland Clinic; Amit Anand – Cleveland Clinic; Elia Pestana-Knight – Cleveland Clinic Epilepsy Center; Jane Timmons-Mitchell – Case western university; krystel Tossone – Case western university; Diane Zemba – Cleveland Clinic; Tatiana Falcone – Cleveland Clinic;

 

Hospitalization costs and mortality in pediatric patients with drug-resistant epilepsy: vagus nerve stimulation therapy versus medical management

Authors: Sandi Lam, Ann and Robert H Lurie Children’s Hospital of Chicago; Lu Zhang – Ann and Robert H Lurie Children’s Hospital; I-Wen Pan – MD Anderson Cancer Center

 

Awareness and perception of first-aid methods for adult epilepsy patients and caregivers

Authors: Rachel FY Wu, Li Ka Shing Faculty of Medicine, The University of Hong Kong; Janet KT Wong – Li Ka Shing Faculty of Medicine, The University of Hong Kong; Ting Gee Annie Chiu – Queen Mary Hospital, The University of Hong Kong; William CY Leung – Queen Mary Hospital, The University of Hong Kong; YH Yuen – The University of Hong Kong; Cheuk Nam Rachel Lo – Queen Mary Hospital, The University of Hong Kong; Richard Shek-kwan Chang – Queen Mary Hospital, The University of Hong Kong

 

Sudden Unexpected Death in Epilepsy in a Canadian Centre: Our experience

Authors: Ana Suller Marti, Western University; Jane Ding – Western University; Jorge G Burneo – Western University; Robert Hammond – Western University; Lee Cyn Ang – Western University; Qi Zhang – Western University

 

Primary Care Provider Attitudes Regarding SUDEP in an Uninsured Population

Authors: Julia Ghering, University of Arizona College of Medicine- Phoenix; Shahrzad Saririan – University of Arizona College of Medicine- Phoenix; Jeffrey Buchhalter – Epilepsy Foundation

 

Quality Improvement Initiative to Reduce Fosphenytoin Administration Time for Status Epilepticus in the Emergency Department

Authors: Jorge Vidaurre, Nationwide Children’s Hospital, The Ohio State University; Jackson Mittlesteadt – Nationwide Children’s Hospital; William Parker – Nationwide Children’s Hospital; Anup D. Patel – The Ohio State University and Nationwide Children’s Hospital; Dara Albert – Nationwide Children’s Hospital

 

Readmissions for Cardiac and Non-cardiac Causes Among those with Epilepsy or Multiple Sclerosis

Authors: H. Nicolas Lemus, Icahn School of Medicine at Mount Sinai Downtown; Parul Agarwal – Icahn School of Medicine at Mount Sinai; Churl-Su Kwon – Icahn School of Medicine at Mount Sinai; Anusha Yeshokumar – Icahn School of Medicine at Mount Sinai; Mandip Dhamoon – Icahn School of Medicine at Mount Sinai; Madhu Mazumdar – Icahn School of Medicine at Mount Sinai; Nathalie Jette – Icahn School of Medicine at Mount Sinai