Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Though we are learning a great deal about SUDEP, it still occurs far too often. It is recognized that SUDEP happens frequently during the night, possibly during sleep. Understanding the connection between night, sleep, and SUDEP may provide clues to improving preventive measures. This webinar reviewed the latest in basic science and clinical research on sleep, circadian rhythms, and SUDEP.